Liverpool are fighting to get back on top in the Premier League with just six games to go, while Southampton could take a big step away from the relegation zone with a victory.
Southampton have failed to score in their last four games against Liverpool registering three losses and a single draw with a combined goal difference of -8.
The difference between the two teams might be found in the big gap in wages. Title-chasing Liverpool’s wage bill is more than twice as big as Southampton’s.
This is our weekly head-to-head finances infographic.